| Name | EPPTB |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3502 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1110781-88-8 |
| Chemical Name | N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide |
| Formula | C20H21F3N2O2 |
| Molecular Weight | 378.39 |
| Purity | >99 % |
| Description | Trace amine 1 (TA 1 ) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA 1 receptor than the rat and human TA 1 receptors (IC 50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA 1 receptor-mediated activation of an inwardly rectifying K + current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D 2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC 50 = 19 nM). |
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