| Name | EPZ 004777 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4725 |
| Prices | $245.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1338466-77-5 |
| Chemical Name | 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Formula | C28H41N7O4 |
| Molecular Weight | 539.67 |
| Purity | >98 % |
| Description | Highly potent DOT1L inhibitor (IC 50 = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL -rearranged cells in vitro . Prolongs survival in a MLL xenograft mouse model. |
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