ER 50891

• Supplier: Tocris Bioscience
• Catalog: 2471
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 187400-85-7
• Chemical Name: 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoicacid
• Formula: C29H24N2O2
• Molecular Weight: 432.51
• Purity: >99 %
• Description: Antagonist of RAR α receptors (IC 50 = 31.2 nM). Displays selective affinity for RAR α (relative IC 50 values are 1.8, 432 and 535 nM for RAR α , RAR γ and RAR β respectively).

Product References

Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor - Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor

Kikuchi K, Tagami K, Hibi S, Yoshimura H, Tokuhara N, Tai K, Hida T, Yamauchi T, Nagai M. Bioorg Med Chem Lett. 2001 May 7;11(9):1215-8.

Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA - Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA

Ren M, Pozzi S, Bistulfi G, Somenzi G, Rossetti S, Sacchi N. Mol Cell Biol. 2005 Dec;25(23):10591-603.

Disruption of retinoic acid receptor alpha reveals the growth promoter face of - Disruption of retinoic acid receptor alpha reveals the growth promoter face of

Somenzi G, Sala G, Rossetti S, Ren M, Ghidoni R, Sacchi N. PLoS One. 2007 Sep 5;2(9):e836.