Erastin

• Supplier: Tocris Bioscience
• Catalog: 3823
• Prices: $195.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 571203-78-6
• Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
• Formula: C30H31ClN4O4
• Molecular Weight: 547.04
• Purity: >98 %
• Description: Antitumor agent; selective for cells expressing oncogenic RAS. Also Ferroptosis activator; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Product References

Identification of genotype-selective antitumor agents using synthetic lethal - Identification of genotype-selective antitumor agents using synthetic lethal

Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Cancer Cell. 2003 Mar;3(3):285-96.

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion - RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion

Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR. Nature. 2007 Jun 14;447(7146):864-8.

Ferroptosis: an iron-dependent form of nonapoptotic cell death. - Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Cell. 2012 May 25;149(5):1060-72.