ERB 041

• Supplier: Tocris Bioscience
• Catalog: 5449
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 524684-52-4
• Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
• Formula: C15H10FNO3
• Molecular Weight: 271.24
• Purity: >99 %
• Description: Potent ER β agonist; displays >200-fold selectivity for ER β over ER α (IC 50 values are 5 and 1216 nM for human ER β and ER α ; 3.1 and 620 nM for rat ER β and ER α ; and 3.7 and 750 nM for mouse ER β and ER α respectively).

Product References

Evaluation of an estrogen receptor-beta agonist in animal models of human - Evaluation of an estrogen receptor-beta agonist in animal models of human

Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, Miller CP, Kharode YP, Marzolf J, Komm BS, Winneker RC, Frail DE, Henderson RA, Zhu Y, Keith JC Jr. Endocrinology. 2003 Oct;144(10):4241-9.

Design and synthesis of aryl diphenolic azoles as potent and selective estrogen - Design and synthesis of aryl diphenolic azoles as potent and selective estrogen

Malamas MS, Manas ES, McDevitt RE, Gunawan I, Xu ZB, Collini MD, Miller CP, Dinh T, Henderson RA, Keith JC Jr, Harris HA. J Med Chem. 2004 Oct 7;47(21):5021-40.

Selective estrogen receptor-beta agonists repress transcription of - Selective estrogen receptor-beta agonists repress transcription of

Cvoro A, Tatomer D, Tee MK, Zogovic T, Harris HA, Leitman DC. J Immunol. 2008 Jan 1;180(1):630-6.