| Name | ETP 45658 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1226 |
| Prices | $195.00, $805.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1198357-79-7 |
| Chemical Name | 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol |
| Formula | C16H17N5O2 |
| Molecular Weight | 311.34 |
| Purity | >98 % |
| Description | PI 3-kinase inhibitor (IC 50 values are 22, 30, 129 and 710 nM for PI 3-K α , PI 3-K δ , PI 3-K β and PI 3-K γ respectively). Also inhibits DNA-PK and mTOR (IC 50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo . |
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Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebria A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soilan D, Ceballos PA, Hernandez AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR. J Biol Chem. 2009 Oct 9;284(41):28392-400.
Hill R, Kalathur RK, Callejas S, Colaco L, Brandao R, Serelde B, Cebria A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W. Breast Cancer Res. 2014 Dec 9;16(6):482.