Exendin-3 (9-39) amide

• Supplier: Tocris Bioscience
• Catalog: 3759
• Prices: $395.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 133514-43-9
• Formula: C149H234N40O47S
• Molecular Weight: 3369.79
• Description: Potent and selective GLP-1 receptor antagonist (K d = 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC 50 = 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.

Product References

Exendin-3, a novel peptide from Heloderma horridum venom, interacts with - Exendin-3, a novel peptide from Heloderma horridum venom, interacts with

Raufman JP, Singh L, Eng J. J Biol Chem. 1991 Feb 15;266(5):2897-902.

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an - Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an

Goke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Goke B. J Biol Chem. 1993 Sep 15;268(26):19650-5.

Cloning and functional expression of the human islet GLP-1 receptor. - Cloning and functional expression of the human islet GLP-1 receptor.

Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C. Diabetes. 1993 Nov;42(11):1678-82.

A role for glucagon-like peptide-1 in the central regulation of feeding. - A role for glucagon-like peptide-1 in the central regulation of feeding.

Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR. Nature. 1996 Jan 4;379(6560):69-72.