FAK Inhibitor 14

• Supplier: Tocris Bioscience
• Catalog: 0523
• Prices: $109.00, $455.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 4506-66-5
• Chemical Name: 1,2,4,5-Benzenetetraminetetrahydrochloride
• Formula: C6H10N4.4HCl
• Molecular Weight: 284.01
• Description: Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC 50 = 1 μ M), promotes cell detachment and inhibits cell adhesion in vitro . Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo .

Product References

A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, - A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride,

Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. J Med Chem. 2008 Dec 11;51(23):7405-16.

A novel small molecule inhibitor of FAK decreases growth of human pancreatic - A novel small molecule inhibitor of FAK decreases growth of human pancreatic

Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG, Golubovskaya VM. Cell Cycle. 2009 Aug;8(15):2435-43. Epub 2009 Aug 1.