Fananserin

• Supplier: Tocris Bioscience
• Catalog: 3414
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 127625-29-0
• Chemical Name: 2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide
• Formula: C23H24FN3O2S
• Molecular Weight: 425.52
• Purity: >99 %
• Description: 5-HT 2A receptor antagonist that also displays high affinity at D 4 receptors (K i values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT 2A , D 4 , H 1 , α 1 , 5-HT 1A and D 2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro (IC 50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo .

Product References

Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. - Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.

Malleron JL, Comte MT, Gueremy C, Peyronel JF, Truchon A, Blanchard JC, Doble A, Piot O, Zundel JL, Huon C, et al.. J Med Chem. 1991 Aug;34(8):2477-83.

Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 - Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2

Doble A, Girdlestone D, Piot O, Allam D, Betschart J, Boireau A, Dupuy A, Gueremy C, Menager J, Zundel JL, et al.. Br J Pharmacol. 1992 Jan;105(1):27-36.

The naphtosultam derivative RP 62203 (fananserin) has high affinity for the - The naphtosultam derivative RP 62203 (fananserin) has high affinity for the

Heuillet E, Petitet F, Mignani S, Malleron JL, Lavayre J, Neliat G, Doble A, Blanchard JC. Eur J Pharmacol. 1996 Oct 24;314(1-2):229-33.