Fasudil hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2645
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 105628-07-7
• Formula: C14H17N3O2S.HCl
• Molecular Weight: 327.83
• Purity: >98 %
• Description: Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC 50 = 10.7 μ M). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo . Ca 2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.

Product References

A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits - A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits

Shirotani M, Yui Y, Hattori R, Kawai C. J Pharmacol Exp Ther. 1991 Nov;259(2):738-44.

Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH - Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH

Arai M, Sasaki Y, Nozawa R. Biochem Pharmacol. 1993 Oct 19;46(8):1487-90.

Neuroprotective properties of a protein kinase inhibitor against - Neuroprotective properties of a protein kinase inhibitor against

Satoh S, Ikegaki I, Suzuki Y, Asano T, Shibuya M, Hidaka H. Br J Pharmacol. 1996 Aug;118(7):1592-6.

Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of - Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of

Sward K, Dreja K, Susnjar M, Hellstrand P, Hartshorne DJ, Walsh MP. J Physiol. 2000 Jan 1;522 Pt 1:33-49.

Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in - Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in

Deng L, Li G, Li R, Liu Q, He Q, Zhang J. Cancer Biol Ther. 2010 Jun 1;9(11):875-84. Epub 2010 Jun 26.