Febuxostat

• Supplier: Tocris Bioscience
• Catalog: 0453
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 144060-53-7
• Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicacid
• Formula: C16H16N2O3S
• Molecular Weight: 316.37
• Purity: >99 %
• Description: Non-purine inhibitor of xanthine oxidase (K i = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

Product References

Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in - Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in

Osada Y, Tsuchimoto M, Fukushima H, Takahashi K, Kondo S, Hasegawa M, Komoriya K. Eur J Pharmacol. 1993 Sep 14;241(2-3):183-8.

An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of - An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of

Okamoto K, Eger BT, Nishino T, Kondo S, Pai EF, Nishino T. J Biol Chem. 2003 Jan 17;278(3):1848-55. Epub 2002 Nov 5.

Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced - Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced

Xu X, Hu X, Lu Z, Zhang P, Zhao L, Wessale JL, Bache RJ, Chen Y. J Card Fail. 2008 Nov;14(9):746-53.