Felodipine

Name Felodipine
Supplier Tocris Bioscience
Catalog 0869
Prices $105.00, $445.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 72509-76-3
Chemical Name 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester
Formula C18H19Cl2NO4
Molecular Weight 384.25
Purity >98 %
Description L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.
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Product References

Vascular selectivity of felodipine: experimental pharmacology. - Vascular selectivity of felodipine: experimental pharmacology.

Ljung B. J Cardiovasc Pharmacol. 1990;15 Suppl 4:S11-6.

Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes - Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes

Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73.

Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ - Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+

Furukawa T, Nukada T, Miura R, Ooga K, Honda M, Watanabe S, Koganesawa S, Isshiki T. J Cardiovasc Pharmacol. 2005 Mar;45(3):241-6.