Ferrostatin 1

• Supplier: Tocris Bioscience
• Catalog: 3523
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 347174-05-4
• Chemical Name: Ethyl3-amino-4-(cyclohexylamino)benzoate
• Formula: C15H22N2O2
• Molecular Weight: 262.35
• Purity: >98 %
• Description: Selective inhibitor of erastin induced ferroptosis (EC 50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Product References

Ferroptosis: an iron-dependent form of nonapoptotic cell death. - Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Cell. 2012 May 25;149(5):1060-72.

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. - Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib.

Louandre C, Ezzoukhry Z, Godin C, Barbare JC, Maziere JC, Chauffert B, Galmiche A. Int J Cancer. 2013 Oct 1;133(7):1732-42.

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease - Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. J Am Chem Soc. 2014 Mar 26;136(12):4551-6.