Fexaramine

• Supplier: Tocris Bioscience
• Catalog: 5180
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 574013-66-4
• Chemical Name: 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester
• Formula: C32H36N2O3
• Molecular Weight: 496.64
• Purity: >97 %
• Description: Potent, selective farnesoid X receptor agonist (EC 50 = 25 nM). Displays no activity at hRXR α , hPPAR α , hPPAR γ , hPPAR δ , mPXR, hPXR, hLXR α , hTR β , hRAR β , mCAR, mERR γ and hVDR receptors.

Product References

A chemical, genetic, and structural analysis of the nuclear bile acid receptor - A chemical, genetic, and structural analysis of the nuclear bile acid receptor

Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. Mol Cell. 2003 Apr;11(4):1079-92.

Discovery and optimization of non-steroidal FXR agonists from natural - Discovery and optimization of non-steroidal FXR agonists from natural

Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. Org Biomol Chem. 2003 Mar 21;1(6):908-20.

Back door modulation of the farnesoid X receptor: design, synthesis, and - Back door modulation of the farnesoid X receptor: design, synthesis, and

Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S. J Med Chem. 2006 Jul 13;49(14):4208-15.