FICZ

• Supplier: Tocris Bioscience
• Catalog: 4344
• Prices: $149.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 172922-91-7
• Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
• Formula: C19H12N2O
• Molecular Weight: 284.31
• Purity: >95 %
• Description: High affinity aryl hydrocarbon receptor (AhR) agonist (K d = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro .

Product References

Structure elucidation of two tryptophan-derived, high affinity Ah receptor - Structure elucidation of two tryptophan-derived, high affinity Ah receptor

Rannug U, Rannug A, Sjoberg U, Li H, Westerholm R, Bergman J. Chem Biol. 1995 Dec;2(12):841-5.

The suggested physiologic aryl hydrocarbon receptor activator and cytochrome - The suggested physiologic aryl hydrocarbon receptor activator and cytochrome

Wincent E, Amini N, Luecke S, Glatt H, Bergman J, Crescenzi C, Rannug A, Rannug U. J Biol Chem. 2009 Jan 30;284(5):2690-6.

AhR sensing of bacterial pigments regulates antibacterial defence. - AhR sensing of bacterial pigments regulates antibacterial defence.

Moura-Alves P, Fae K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tummler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH. Nature. 2014 Aug 28;512(7515):387-92.