| Name | FIIN 1 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5304 |
| Prices | $225.00, $925.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1256152-35-8 |
| Chemical Name | N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide |
| Formula | C32H39Cl2N7O4 |
| Molecular Weight | 693.06 |
| Purity | >96 % |
| Description | Potent, irreversible FGFR inhibitor (K d values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (K d values are 32, 120 and 210 nM respectively); displays limited activity (K d >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC 50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044). |
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