Fisetin

• Supplier: Tocris Bioscience
• Catalog: 3600
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Antioxidant
• Cas Number: 528-48-3
• Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
• Formula: C15H10O6
• Molecular Weight: 286.24
• Purity: >98 %
• Description: Naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.

Product References

Mechanisms for the inhibition of DNA methyltransferases by tea catechins and - Mechanisms for the inhibition of DNA methyltransferases by tea catechins and

Lee WJ, Shim JY, Zhu BT. Mol Pharmacol. 2005 Oct;68(4):1018-30. Epub 2005 Jul 21.

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol - Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol

Lu H, Chang DJ, Baratte B, Meijer L, Schulze-Gahmen U. J Med Chem. 2005 Feb 10;48(3):737-43.

Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin - Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin

Haddad AQ, Fleshner N, Nelson C, Saour B, Musquera M, Venkateswaran V, Klotz L. Nutr Cancer. 2010;62(5):668-81.

ERK activation by the polyphenols fisetin and resveratrol provides - ERK activation by the polyphenols fisetin and resveratrol provides

Maher P, Dargusch R, Bodai L, Gerard PE, Purcell JM, Marsh JL. Hum Mol Genet. 2011 Jan 15;20(2):261-70.

Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for - Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for

Adhami VM, Syed DN, Khan N, Mukhtar H. Biochem Pharmacol. 2012 Nov 15;84(10):1277-81.