FK 228

• Supplier: Tocris Bioscience
• Catalog: 5440
• Prices: $249.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 128517-07-7
• Chemical Name: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl],cyclic(3-5)disulfide
• Formula: C24H36N4O6S2
• Molecular Weight: 540.7
• Purity: >98 %
• Description: Potent and selective inhibitor of class I histone deacetylases (HDACs) (IC 50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

Product References

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone - FK228 (depsipeptide) as a natural prodrug that inhibits class I histone

Furumai R, Matsuyama A, Kobashi N, Lee KH, Nishiyama M, Nakajima H, Tanaka A, Komatsu Y, Nishino N, Yoshida M, Horinouchi S. Cancer Res. 2002 Sep 1;62(17):4916-21.

Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and - Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and

Sasakawa Y, Naoe Y, Inoue T, Sasakawa T, Matsuo M, Manda T, Mutoh S. Cancer Lett. 2003 Jun 10;195(2):161-8.

Involvement of extracellular signal-regulated kinase activation in human - Involvement of extracellular signal-regulated kinase activation in human

Matsubara H, Watanabe M, Imai T, Yui Y, Mizushima Y, Hiraumi Y, Kamitsuji Y, Watanabe K, Nishijo K, Toguchida J, Nakahata T, Adachi S. J Pharmacol Exp Ther. 2009 Mar;328(3):839-48.