FK 506

Name FK 506
Supplier Tocris Bioscience
Catalog 3105
Prices $139.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 104987-11-3
Chemical Name (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Formula C44H69NO12
Molecular Weight 804.02
Purity >99 %
Description Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo . Analog ( ascomycin , Cat. No. 4210) also available.
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Product References

The complex of FK506-binding protein 12 and FK506 inhibits calcineurin - The complex of FK506-binding protein 12 and FK506 inhibits calcineurin

Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR. J Immunol. 1995 Feb 15;154(4):1846-51.

Tissue distribution and abundance of human FKBP51, and FK506-binding protein that - Tissue distribution and abundance of human FKBP51, and FK506-binding protein that

Baughman G, Wiederrecht GJ, Chang F, Martin MM, Bourgeois S. Biochem Biophys Res Commun. 1997 Mar 17;232(2):437-43.

Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants - Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants

Sierra-Paredes G, Sierra-Marcuno G. CNS Neurosci Ther. 2008 Spring;14(1):36-46. doi: