FK 866 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3631
• Prices: $179.00, $745.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamidehydrochloride
• Formula: C24H29N3O2.HCl
• Molecular Weight: 427.97
• Purity: >98 %
• Description: Non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, visfatin, PBEF1) (K i = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC 50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

Product References

FK866, a highly specific noncompetitive inhibitor of nicotinamide - FK866, a highly specific noncompetitive inhibitor of nicotinamide

Hasmann M, Schemainda I. Cancer Res. 2003 Nov 1;63(21):7436-42.

Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor - Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor

Galli U, Ercolano E, Carraro L, Blasi Roman CR, Sorba G, Canonico PL, Genazzani AA, Tron GC, Billington RA. ChemMedChem. 2008 May;3(5):771-9.

Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of - Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of

Travelli C, Drago V, Maldi E, Kaludercic N, Galli U, Boldorini R, Di Lisa F, Tron GC, Canonico PL, Genazzani AA. J Pharmacol Exp Ther. 2011 Sep;338(3):829-40.