FK 888

• Supplier: Tocris Bioscience
• Catalog: 4808
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 138449-07-7
• Chemical Name: (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
• Formula: C36H36N4O4
• Molecular Weight: 588.69
• Purity: >98 %
• Description: Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

Product References

Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, - Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist,

Fujii T, Murai M, Morimoto H, Maeda Y, Yamaoka M, Hagiwara D, Miyake H, Ikari N, Matsuo M. Br J Pharmacol. 1992 Nov;107(3):785-9.

Effects of an NK1 receptor antagonist, FK888, on constriction and plasma - Effects of an NK1 receptor antagonist, FK888, on constriction and plasma

Murai M, Maeda Y, Hagiwara D, Miyake H, Ikari N, Matsuo M, Fujii T. Eur J Pharmacol. 1993 May 12;236(1):7-13.

Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for - Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for

Aramori I, Morikawa N, Zenkoh J, O'Donnell N, Iwami M, Kojo H, Notsu Y, Okuhara M, Ono S, Nakanishi S. Eur J Pharmacol. 1994 Oct 14;269(2):277-81.