Floxuridine

• Supplier: Tocris Bioscience
• Catalog: 5172
• Prices: $79.00
• Sizes: 50 mg
• Cas Number: 50-91-9
• Chemical Name: 5-Fluoro-2'-deoxyuridine
• Formula: C9H11FN2O5
• Molecular Weight: 246.19
• Purity: >98 %
• Description: Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Product References

Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate - Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate

Bapat AR, Zarow C, Danenberg PV. J Biol Chem. 1983 Apr 10;258(7):4130-6.

Participation of DNA repair in the response to 5-fluorouracil. - Participation of DNA repair in the response to 5-fluorouracil.

Wyatt MD, Wilson DM 3rd. Cell Mol Life Sci. 2009 Mar;66(5):788-99.

Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but - Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but

Huehls AM, Wagner JM, Huntoon CJ, Geng L, Erlichman C, Patel AG, Kaufmann SH, Karnitz LM. Cancer Res. 2011 Jul 15;71(14):4944-54.