Fludarabine

• Supplier: Tocris Bioscience
• Catalog: 3764
• Prices: $129.00, $509.00
• Sizes: 10 mg, 50 mg
• Cas Number: 21679-14-1
• Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
• Formula: C10H12FN5O4
• Molecular Weight: 285.23
• Purity: >99 %
• Description: Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo .

Product References

In vitro evaluation of fludarabine in combination with cyclophosphamide and/or - In vitro evaluation of fludarabine in combination with cyclophosphamide and/or

Bellosillo B, Villamor N, Colomer D, Pons G, Montserrat E, Gil J. Blood. 1999 Oct 15;94(8):2836-43.

Antitumor activity of fludarabine against human multiple myeloma in vitro and in - Antitumor activity of fludarabine against human multiple myeloma in vitro and in

Meng H, Yang C, Ni W, Ding W, Yang X, Qian W. Eur J Haematol. 2007 Dec;79(6):486-93. Epub 2007 Nov 1.

Fludarabine prevents smooth muscle proliferation in vitro and neointimal - Fludarabine prevents smooth muscle proliferation in vitro and neointimal

Torella D, Curcio A, Gasparri C, Galuppo V, De Serio D, Surace FC, Cavaliere AL, Leone A, Coppola C, Ellison GM, Indolfi C. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2935-43. Epub 2007 Feb 9.