5'-Fluoroindirubinoxime

• Supplier: Tocris Bioscience
• Catalog: 4064
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 861214-33-7
• Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
• Formula: C16H10FN3O2
• Molecular Weight: 295.27
• Purity: >99 %
• Description: Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC 50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Product References

Antitumor activity of novel indirubin derivatives in rat tumor model. - Antitumor activity of novel indirubin derivatives in rat tumor model.

Kim SA, Kim YC, Kim SW, Lee SH, Min JJ, Ahn SG, Yoon JH. Clin Cancer Res. 2007 Jan 1;13(1):253-9.

Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. - Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.

Krivogorsky B, Grundt P, Yolken R, Jones-Brando L. Antimicrob Agents Chemother. 2008 Dec;52(12):4466-9.

Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity - Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity

Choi SJ, Moon MJ, Lee SD, Choi SU, Han SY, Kim YC. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2033-7.