5-Fluoroorotic acid

• Supplier: Tocris Bioscience
• Catalog: 4033
• Prices: $149.00
• Sizes: 100 mg
• Cas Number: 703-95-7
• Chemical Name: 5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicacid
• Formula: C5H3FN2O4
• Molecular Weight: 174.09
• Purity: >99 %
• Description: Reagent for selection of Orotidine-5'-phosphate decarboxylase mutants of Saccharomyces cerevisiae .

Product References

An alternative molecular mechanism of action of 5-fluorouracil, a potent - An alternative molecular mechanism of action of 5-fluorouracil, a potent

Ghoshal K, Jacob ST. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75.

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. - Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.

Peters GJ, Backus HH, Freemantle S, van Triest B, Codacci-Pisanelli G, van der Wilt CL, Smid K, Lunec J, Calvert AH, Marsh S, McLeod HL, Bloemena E, Meijer S, Jansen G, van Groeningen CJ, Pinedo HM. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):194-205.

5-fluorouracil: mechanisms of action and clinical strategies. - 5-fluorouracil: mechanisms of action and clinical strategies.

Longley DB, Harkin DP, Johnston PG. Nat Rev Cancer. 2003 May;3(5):330-8.