Flupirtine maleate

Name Flupirtine maleate
Supplier Tocris Bioscience
Catalog 5535
Prices $109.00, $459.00
Sizes 10 mg, 50 mg
Cas Number 75507-68-5
Chemical Name N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamicacidethylestermaleate
Formula C15H17FN4O2.C4H4O4
Molecular Weight 420.4
Purity >98 %
Description Non-opioid analgesic with muscle relaxant properties. Activates K V 7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABA A receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.
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Product References

Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. - Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist.

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The potassium channel modulator flupirtine shifts the frequency-response function - The potassium channel modulator flupirtine shifts the frequency-response function

Azad SC, Eder M, Simon W, Hapfelmeier G, Dodt HU, Zieglgansberger W, Rammes G. Neurosci Lett. 2004 Nov 11;370(2-3):186-90.

Molecular expression and pharmacological identification of a role for K(v)7 - Molecular expression and pharmacological identification of a role for K(v)7

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Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid - Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid

Klinger F, Geier P, Dorostkar MM, Chandaka GK, Yousuf A, Salzer I, Kubista H, Boehm S. Br J Pharmacol. 2012 Jul;166(5):1631-42.