Fluticasone propionate

• Supplier: Tocris Bioscience
• Catalog: 2226
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 80474-14-2
• Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioicacidfluoromethylester
• Formula: C25H31F3O5S
• Molecular Weight: 500.57
• Purity: >98 %
• Description: High affinity, selective glucocorticoid receptor agonist (K d = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC 50 = 3.7 nM) in vitro . Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates K V 1 channels (EC 50 = 37 nM).

Product References

The anti-inflammatory profile of fluticasone propionate. - The anti-inflammatory profile of fluticasone propionate.

Johnson M. Allergy. 1995;50(23 Suppl):11-4.

Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, - Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide,

Zhang X, Moilanen E, Kankaanranta H. Eur J Pharmacol. 2000 Oct 20;406(3):325-32.

Potentiation of the Kv1 family K(+) channel by cortisone analogues. - Potentiation of the Kv1 family K(+) channel by cortisone analogues.

Pan Y, Levin EJ, Quick M, Zhou M. ACS Chem Biol. 2012 Oct 19;7(10):1641-6.