Forskolin

• Supplier: Tocris Bioscience
• Catalog: 1921
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 66575-29-9
• Chemical Name: [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
• Formula: C22H34O7
• Molecular Weight: 410.51
• Purity: >98 %
• Description: Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742 , 4423 and 4703 ). Also available as part of the PKA Tocriset™ .

Product References

Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics - Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics

Awad JA, Johnson RA, Jakobs KH, Schultz G. J Biol Chem. 1983 Mar 10;258(5):2960-5.

Structure-activity relationships for activation of adenylate cyclase by the - Structure-activity relationships for activation of adenylate cyclase by the

Seamon KB, Daly JW, Metzger H, de Souza NJ, Reden J. J Med Chem. 1983 Mar;26(3):436-9.

Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple - Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple

Laurenza A, Sutkowski EM, Seamon KB. Trends Pharmacol Sci. 1989 Nov;10(11):442-7.

cAMP induces neuronal differentiation of mesenchymal stem cells via activation of - cAMP induces neuronal differentiation of mesenchymal stem cells via activation of

Kim SS, Choi JM, Kim JW, Ham DS, Ghil SH, Kim MK, Kim-Kwon Y, Hong SY, Ahn SC, Kim SU, Lee YD, Suh-Kim H. Neuroreport. 2005 Aug 22;16(12):1357-61.

Pluripotent stem cells induced from mouse somatic cells by small-molecule - Pluripotent stem cells induced from mouse somatic cells by small-molecule

Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. Science. 2013 Aug 9;341(6146):651-4.