Fostriecin sodium salt

• Supplier: Tocris Bioscience
• Catalog: 1099
• Prices: $269.00
• Sizes: 50 µg
• Function Type: Inhibitor
• Cas Number: 87860-39-7
• Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt
• Formula: C19H26O9PNa
• Molecular Weight: 452.37
• Purity: >98 %
• Description: Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC 50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC 50 = 40 μ M) and protein phosphatase type 1 (PP1) (IC 50 = 131 μ M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo . Originally identified as an antitumor antibiotic from Streptomyces pulveraceous .

Product References

Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, - Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy,

Tunac JB, Graham BD, Dobson WE. J Antibiot (Tokyo). 1983 Dec;36(12):1595-600.

Fostriecin, an antitumor antibiotic with inhibitory activity against - Fostriecin, an antitumor antibiotic with inhibitory activity against

Walsh AH, Cheng A, Honkanen RE. FEBS Lett. 1997 Oct 27;416(3):230-4.

Purification of protein phosphatase 4 catalytic subunit: inhibition by the - Purification of protein phosphatase 4 catalytic subunit: inhibition by the

Hastie CJ, Cohen PT. FEBS Lett. 1998 Jul 24;431(3):357-61.