FR 122047 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2826
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 130717-51-0
• Chemical Name: 1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazinehydrochloride
• Formula: C23H25N3O3S.HCl
• Molecular Weight: 459.99
• Purity: >98 %
• Description: Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

Product References

The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. - The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor.

Dohi M, Sakata Y, Seki J, Namikawa Y, Fujisaki J, Tanaka A, Takasugi H, Motoyama Y, Yoshida K. Eur J Pharmacol. 1993 Oct 19;243(2):179-84.

Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. - Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis.

Tanaka A, Sakai H, Motoyama Y, Ishikawa T, Takasugi H. J Med Chem. 1994 Apr 15;37(8):1189-99.

The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, - The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor,

Ochi T, Motoyama Y, Goto T. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54.

Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat - Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat

Ochi T, Goto T. Br J Pharmacol. 2002 Feb;135(3):782-8.