FR 139317

• Supplier: Tocris Bioscience
• Catalog: 1507
• Prices: $219.00, $905.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 142375-60-8
• Chemical Name: N-[N-[N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-3-(2-pyridinyl)-D-alanine
• Formula: C33H44N6O5
• Molecular Weight: 604.75
• Purity: >99 %
• Description: A highly potent and selective ET A endothelin receptor antagonist (K i values are 1 nM and 7.3 μ M at ET A and ET B subtypes respectively). Active in vivo .

Product References

Subtype selectivity of a novel endothelin antagonist, FR139317, for the two - Subtype selectivity of a novel endothelin antagonist, FR139317, for the two

Aramori I, Nirei H, Shoubo M, Sogabe K, Nakamura K, Kojo H, Notsu Y, Ono T, Nakanishi S. Mol Pharmacol. 1993 Feb;43(2):127-31.

Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor - Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor

Sogabe K, Nirei H, Shoubo M, Nomoto A, Ao S, Notsu Y, Ono T. J Pharmacol Exp Ther. 1993 Mar;264(3):1040-6.

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and - Endothelins: molecular biology, biochemistry, pharmacology, physiology, and

Rubanyi GM, Polokoff MA. Pharmacol Rev. 1994 Sep;46(3):325-415.

Role of endothelin ET(A)- and ET(B)-receptors in haemodynamic compensation - Role of endothelin ET(A)- and ET(B)-receptors in haemodynamic compensation

Palacios B, Lim SL, Pang CC. Br J Pharmacol. 2002 Feb;135(4):876-82.