FR 171113

Name FR 171113
Supplier Tocris Bioscience
Catalog 1210
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 173904-50-2
Chemical Name 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-aceticacidmethylester
Formula C19H11Cl3N2O4S
Molecular Weight 469.73
Purity >98 %
Description Protease-activated receptor 1 (PAR 1 ) antagonist. Exhibits potent antiplatelet activity in vitro ; inhibits thrombin TRAP-6-induced platelet aggregation (IC 50 = 2.5 μ M) with no effect on coagulation time.
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Product References

In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor - In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor

Kato Y, Kita Y, Nishio M, Hirasawa Y, Ito K, Yamanaka T, Motoyama Y, Seki J. Eur J Pharmacol. 1999 Nov 19;384(2-3):197-202.

Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, - Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist,

Kato Y, Kita Y, Hirasawa-Taniyama Y, Nishio M, Mihara K, Ito K, Yamanaka T, Seki J, Miyata S, Mutoh S. Eur J Pharmacol. 2003 Jul 25;473(2-3):163-9.