FTI 277

Name FTI 277
Supplier Tocris Bioscience
Catalog 4751
Prices $129.00
Sizes 1 mg
Cas Number 1217447-06-7
Chemical Name N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methioninemethylestertrifluoroacetatesalt
Formula C22H29N3O3S2.C2HF3O2
Molecular Weight 561.64
Purity >95 %
Description Prodrug form of FTI 276 (Cat. No. 2406) that inhibits farnesyltransferase (FTase) (IC 50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC 50 values are 0.1 and 10 μ M respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
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Product References

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by - Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. J Biol Chem. 1995 Nov 10;270(45):26802-6.

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a - Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a

Sun J, Qian Y, Hamilton AD, Sebti SM. Cancer Res. 1995 Oct 1;55(19):4243-7.