Fumitremorgin C

• Supplier: Tocris Bioscience
• Catalog: 1768
• Prices: $205.00
• Sizes: 250 µg
• Cas Number: 118974-02-0
• Chemical Name: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
• Formula: C22H25N3O3
• Molecular Weight: 379.45
• Purity: >98 %
• Description: Chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog ( Ko 143 , Cat. No. 3241) also available.

Product References

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells - Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells

Rabindran SK, He H, Singh M, Brown E, Collins KI, Annable T, Greenberger LM. Cancer Res. 1998 Dec 15;58(24):5850-8.

Fumitremorgin C reverses multidrug resistance in cells transfected with the - Fumitremorgin C reverses multidrug resistance in cells transfected with the

Rabindran SK, Ross DD, Doyle LA, Yang W, Greenberger LM. Cancer Res. 2000 Jan 1;60(1):47-50.