Fumonisin B1

• Supplier: Tocris Bioscience
• Catalog: 2876
• Prices: $105.00
• Sizes: 1 mg
• Cas Number: 116355-83-0
• Chemical Name: 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylicacidester.
• Formula: C34H59NO15
• Molecular Weight: 721.83
• Description: Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively.

Product References

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo - Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo

Merrill AH Jr, van Echten G, Wang E, Sandhoff K. J Biol Chem. 1993 Dec 25;268(36):27299-306.

Cannabinoids inhibit glioma cell invasion by down-regulating matrix - Cannabinoids inhibit glioma cell invasion by down-regulating matrix

Blazquez C, Salazar M, Carracedo A, Lorente M, Egia A, Gonzalez-Feria L, Haro A, Velasco G, Guzman M. Cancer Res. 2008 Mar 15;68(6):1945-52.