| Name | G10 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3577 |
| Prices | $125.00, $525.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Activator |
| Cas Number | 702662-50-8 |
| Chemical Name | 4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide |
| Formula | C21H16ClFN2O3S |
| Molecular Weight | 430.88 |
| Purity | >98 % |
| Description | Activator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFN α and IFN γ gene expression in human fibroblasts. Exhibits no effect on NF- κ B signaling. Blocks viral replication in vitro . |
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Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, Bologa CG, Leitao A, Brailoiu E, Deliu E, Dun NJ, Sklar LA, Hathaway HJ, Arterburn JB, Oprea TI, Prossnitz ER. Nat Chem Biol. 2009 Jun;5(6):421-7.
Hutchens MP, Fujiyoshi T, Komers R, Herson PS, Anderson S. Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F377-85. doi: