G-36

• Supplier: Tocris Bioscience
• Catalog: 3678
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1392487-51-2
• Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
• Formula: C22H22BrNO2
• Molecular Weight: 412.33
• Purity: >99 %
• Description: Antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ER α . Also inhibits estrogen-mediated calcium mobilization (IC 50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Product References

Identification of a GPER/GPR30 antagonist with improved estrogen receptor - Identification of a GPER/GPR30 antagonist with improved estrogen receptor

Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, Oprea TI, Yamaguchi Y, Hayashi S, Sklar LA, Hathaway HJ, Arterburn JB, Prossnitz ER. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66. doi:

The G-protein-coupled estrogen receptor GPER in health and disease. - The G-protein-coupled estrogen receptor GPER in health and disease.

Prossnitz ER, Barton M. Nat Rev Endocrinol. 2011 Aug 16;7(12):715-26.