GA3-AM

Name GA3-AM
Supplier Tocris Bioscience
Catalog 4131
Prices $65.00, $275.00
Sizes 10 mg, 50 mg
Cas Number 1373154-68-7
Chemical Name (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-aceticacid(acetyloxy)methylester
Formula C22H26O8
Molecular Weight 418.44
Purity >90 %
Description Gibberellin-analog (GA 3 ) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA 3 -AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA 3 , which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC 50 = 310 nM). GA 3 and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.
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Product References

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