Gabexate mesylate

• Supplier: Tocris Bioscience
• Catalog: 0806
• Prices: $129.00, $489.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 56974-61-9
• Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoicacidethylestermesylate
• Formula: C16H23N3O4.CH3SO3H
• Molecular Weight: 417.48
• Purity: >98 %
• Description: Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC 50 values are 9.4, 30, 41 and 110 μ M respectively). Antithrombotic in vitro and in vivo . Also inhibits LPS-induced TNF- α production, probably by inhibiting NF- κ B and AP-1 activation.

Product References

Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 - Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1

Tamura Y, Hirado M, Okamura K, Minato Y, Fujii S. Biochim Biophys Acta. 1977 Oct 13;484(2):417-22.

FOY: [ethyl P-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine - FOY: [ethyl P-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine

Ohno H, Kosaki G, Kambayashi J, Imaoka S, Hirata F. Thromb Res. 1980 Aug 15-Sep 1;19(4-5):579-88.

FOY: [ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine - FOY: [ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine

Ohno H, Kambayashi J, Chang SW, Kosaki G. Thromb Res. 1981 Dec 1-15;24(5-6):445-52.

Gabexate mesilate, a synthetic protease inhibitor, inhibits - Gabexate mesilate, a synthetic protease inhibitor, inhibits

Yuksel M, Okajima K, Uchiba M, Okabe H. J Pharmacol Exp Ther. 2003 Apr;305(1):298-305.