Name | Gadolinium chloride |
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Supplier | Tocris Bioscience |
Catalog | 1798 |
Prices | $49.00 |
Sizes | 50 mg |
Function Type | Agonist |
Cas Number | 10138-52-0 |
Formula | GdCl3 |
Molecular Weight | 263.61 |
Description | Calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels. |
Supplier Page | Shop |
Nagata K, Zheng L, Madathany T, Castiglioni AJ, Bartles JR, Garcia-Anoveros J. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):353-8. Epub 2007 Dec 27.
Nishitani WS, Saif TA, Wang Y. PLoS One. 2011;6(10):e26181.
Del Favero G, Florio C, Codan B, Sosa S, Poli M, Sbaizero O, Molgo J, Tubaro A, Lorenzon P. Chem Res Toxicol. 2012 Sep 17;25(9):1912-20.
Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ. Nature. 2012 Dec 6;492(7427):123-7.