Galeterone

• Supplier: Tocris Bioscience
• Catalog: 0686
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 851983-85-2
• Chemical Name: (3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol
• Formula: C26H32N2O
• Molecular Weight: 388.55
• Purity: >98 %
• Description: CYP17 inhibitor (IC 50 = 300 nM) and androgen receptor antagonist (IC 50 = 384 nM in PC3-AR cells). Inhibits DHT-stimulated prostate cancer cell proliferation in vitro . Exhibits antitumor activity in SCID mice bearing prostate cancer xenografts.

Product References

Small molecule disruption of G protein beta gamma subunit signaling inhibits - Small molecule disruption of G protein beta gamma subunit signaling inhibits

Lehmann DM, Seneviratne AM, Smrcka AV. Mol Pharmacol. 2008 Feb;73(2):410-8. Epub 2007 Nov 15.

Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor - Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor

Ukhanov K, Brunert D, Corey EA, Ache BW. J Neurosci. 2011 Jan 5;31(1):273-80.