Galnon

• Supplier: Tocris Bioscience
• Catalog: 4795
• Prices: $129.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 475115-35-6
• Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
• Formula: C40H46N4O6
• Molecular Weight: 678.83
• Description: Novel non-peptide galanin GAL 1 and GAL 2 receptor agonist (K i values are 11.7 and 34.1 μ M respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo ; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.

Product References

Anticonvulsant activity of a nonpeptide galanin receptor agonist. - Anticonvulsant activity of a nonpeptide galanin receptor agonist.

Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hokfelt T, Wasterlain C, Bartfai T, Langel U. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41.

Regulation of feeding by galnon. - Regulation of feeding by galnon.

Abramov U, Floren A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U. Neuropeptides. 2004 Feb;38(1):55-61.

A role for galanin in antidepressant actions with a focus on the dorsal raphe - A role for galanin in antidepressant actions with a focus on the dorsal raphe

Lu X, Barr AM, Kinney JW, Sanna P, Conti B, Behrens MM, Bartfai T. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):874-9. Epub 2005 Jan 12.

Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release - Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release

Quynh NT, Islam MS, Floren A, Bartfai T, Langel U, Ostenson CG. Biochem Biophys Res Commun. 2005 Mar 4;328(1):213-20.