GANT 61

• Supplier: Tocris Bioscience
• Catalog: 3889
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 500579-04-4
• Chemical Name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
• Formula: C27H35N5
• Molecular Weight: 429.61
• Purity: >98 %
• Description: GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC 50 ~ 5 μ M). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo . Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.

Product References

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule - Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule

Lauth M, Bergstrom A, Shimokawa T, Toftgard R. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60. Epub 2007 May 9.

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA - Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA

Mazumdar T, Devecchio J, Agyeman A, Shi T, Houghton JA. Cancer Res. 2011 Sep 1;71(17):5904-14.

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R - GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R

Fu J, Rodova M, Roy SK, Sharma J, Singh KP, Srivastava RK, Shankar S. Cancer Lett. 2013 Mar 1;330(1):22-32.