Gap 26

• Supplier: Tocris Bioscience
• Catalog: 3191
• Prices: $255.00
• Sizes: 1 mg
• Function Type: Blocker
• Cas Number: 197250-15-0
• Formula: C70H107N19O19S
• Molecular Weight: 1550.79
• Description: Peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC 50 = 28.4 mM). Also inhibits IP 3 -induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

Product References

Peptides homologous to extracellular loop motifs of connexin 43 reversibly - Peptides homologous to extracellular loop motifs of connexin 43 reversibly

Chaytor AT, Evans WH, Griffith TM. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110.

Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked - Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked

Braet K, Vandamme W, Martin PE, Evans WH, Leybaert L. Cell Calcium. 2003 Jan;33(1):37-48.