Gap19

• Supplier: Tocris Bioscience
• Catalog: 1476
• Prices: $195.00
• Sizes: 1 mg
• Function Type: Blocker
• Cas Number: 1507930-57-5
• Formula: C55H96N14O13
• Molecular Weight: 1161.45
• Description: Selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Product References

Connexin 43 impacts on mitochondrial potassium uptake. - Connexin 43 impacts on mitochondrial potassium uptake.

Boengler K, Ungefug E, Heusch G, Leybaert L, Schulz R. Front Pharmacol. 2013 Jun 6;4:73.

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial - Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial

Wang N, De Vuyst E, Ponsaerts R, Boengler K, Palacios-Prado N, Wauman J, Lai CP, De Bock M, Decrock E, Bol M, Vinken M, Rogiers V, Tavernier J, Evans WH, Naus CC, Bukauskas FF, Sipido KR, Heusch G, Schulz R, Bultynck G, Leybaert L. Basic Res Cardiol. 2013 Jan;108(1):309.

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap - The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap

Abudara V, Bechberger J, Freitas-Andrade M, De Bock M, Wang N, Bultynck G, Naus CC, Leybaert L, Giaume C. Front Cell Neurosci. 2014 Oct 21;8:306.