Garcinol

• Supplier: Tocris Bioscience
• Catalog: 5353
• Prices: $129.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 78824-30-3
• Chemical Name: (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione
• Formula: C38H50O6
• Molecular Weight: 602.8
• Purity: >98 %
• Description: Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC 50 values are 5 and 7 μ M, respectively). Promotes expansion of human HSCs ex vivo . Causes reversal of EMT and inhibits β -catenin in breast cancer cell lines MDA-MB-231 and BT-549.

Product References

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase - Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase

Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK. J Biol Chem. 2004 Aug 6;279(32):33716-26. Epub 2004 May 19.

Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent - Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent

Nishino T, Wang C, Mochizuki-Kashio M, Osawa M, Nakauchi H, Iwama A. PLoS One. 2011;6(9):e24298.

Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading - Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading

Ahmad A, Sarkar SH, Bitar B, Ali S, Aboukameel A, Sethi S, Li Y, Bao B, Kong D, Banerjee S, Padhye SB, Sarkar FH. Mol Cancer Ther. 2012 Oct;11(10):2193-201.