GaTx2

Name GaTx2
Supplier Tocris Bioscience
Catalog 3849
Prices $319.00
Sizes 100 µg
Function Type Blocker
Cas Number 194665-85-5
Formula C125H199N39O47S6
Molecular Weight 3192.54
Description Very high affinity ClC-2 blocker (apparent K D ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABA C , CaCC and K V 1.2.
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Product References

Isolation and characterization of a high affinity peptide inhibitor of ClC-2 - Isolation and characterization of a high affinity peptide inhibitor of ClC-2

Thompson CH, Olivetti PR, Fuller MD, Freeman CS, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA. J Biol Chem. 2009 Sep 18;284(38):26051-62.

Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. - Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.

Schiffhauer ES, Vij N, Kovbasnjuk O, Kang PW, Walker D, Lee S, Zeitlin PL. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L324-31. doi: