Gavestinel

• Supplier: Tocris Bioscience
• Catalog: 4911
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 153436-38-5
• Chemical Name: 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylicacidsodiumsalt
• Formula: C18H11Cl2N2O3Na
• Molecular Weight: 397.19
• Purity: >98 %
• Description: Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .

Product References

Substituted indole-2-carboxylates as in vivo potent antagonists acting as the - Substituted indole-2-carboxylates as in vivo potent antagonists acting as the

Di Fabio R, Capelli AM, Conti N, Cugola A, Donati D, Feriani A, Gastaldi P, Gaviraghi G, Hewkin CT, Micheli F, Missio A, Mugnaini M, Pecunioso A, Quaglia AM, Ratti E, Rossi L, Tedesco G, Trist DG, Reggiani A. J Med Chem. 1997 Mar 14;40(6):841-50.

Receptor binding characteristics of the novel NMDA receptor glycine site - Receptor binding characteristics of the novel NMDA receptor glycine site

Mugnaini M, Dal Forno G, Corsi M, Bunnemann B. Eur J Pharmacol. 2000 Mar 17;391(3):233-41.

Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in - Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in

Kajbaf M, Barnaby RJ, Bottacini M, Bertolotti L, Ismail IM, Cholerton TJ, Pellegatti M. Xenobiotica. 2003 Apr;33(4):415-28.