GBR 12909 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0513
• Prices: $85.00, $359.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 67469-78-7
• Chemical Name: 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazinedihydrochloride
• Formula: C28H32F2N2O.2HCl
• Molecular Weight: 523.49
• Purity: >98 %
• Description: Potent, competitive inhibitor of dopamine uptake (K i = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC 50 = 48 nM). Centrally active following systemic administration.

Product References

Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors - Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors

Heikkila RE, Manzino L. Eur J Pharmacol. 1984 Aug 17;103(3-4):241-8.

The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. - The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.

Andersen PH. Eur J Pharmacol. 1989 Aug 3;166(3):493-504.

GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma - GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma

Contreras PC, Bremer ME, Rao TS. Life Sci. 1990;47(22):PL133-7.

Pharmacological characterization of the discriminative-stimulus effects of GBR - Pharmacological characterization of the discriminative-stimulus effects of GBR

Melia KF, Spealman RD. J Pharmacol Exp Ther. 1991 Aug;258(2):626-32.