GC 1

• Supplier: Tocris Bioscience
• Catalog: 0420
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 211110-63-3
• Chemical Name: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]aceticacid
• Formula: C20H24O4
• Molecular Weight: 328.4
• Purity: >98 %
• Description: Thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TR α receptors (K D values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T 3 in vitro at TR α 1 and TR β 1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

Product References

A high-affinity subtype-selective agonist ligand for the thyroid hormone - A high-affinity subtype-selective agonist ligand for the thyroid hormone

Chiellini G, Apriletti JW, Yoshihara HA, Baxter JD, Ribeiro RC, Scanlan TS. Chem Biol. 1998 Jun;5(6):299-306.

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates - Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates

Johansson L, Rudling M, Scanlan TS, Lundasen T, Webb P, Baxter J, Angelin B, Parini P. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302. Epub 2005 Jul 8.

The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat - The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat

Columbano A, Pibiri M, Deidda M, Cossu C, Scanlan TS, Chiellini G, Muntoni S, Ledda-Columbano GM. Endocrinology. 2006 Jul;147(7):3211-8. Epub 2006 Mar 30.